control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk)
| PAG Title | control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk) |
| PAG ID | WAG001254 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | The differentiation of muscle cells is transcriptiolly regulated, in part by the myocyte enhancer factor-2, MEF2. During myogenesis MEF2 binds to MyoD and other basic helix-loop-helix factors to activate transcription of genes involved in muscle cell differentiation. Transcriptiol activation by MEF2 is blocked by interaction with HDAC5 and other histone deacetylases. In undifferentiated myoblasts, HDAC5 is present in the nucleus where it binds to MEF2 to block activation of muscle genes. When activated by IGF-1 sigling, CaM kise phosphorylates HDAC proteins, causing them to be exported from the nucleus, releasing the block on MEF2 transcriptiol activation and allowing differentiation to proceed. Transcription cofactors also interact with MEF2 to contribute to gene regulation and myogenesis. The transcriptiol regulator NFAT, for example, acts as a cofactor for MEF2 when calcium and calcineurin sigling activate it. |
| Species | Homo sapiens |
| nCoCo Score | 419 |
| Base PAG ID | WAG001254 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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